(More information)īiotin cannot be synthesized by mammalian cells and must be obtained from exogenous sources. (More information)ĭefinitive evidence that establishes whether biotin supplementation improves glucose and lipid homeostasis in individuals with type 2 diabetes mellitus is currently lacking, but suggestive observations have been published. Yet, results of animal studies and meta-analyses of human clinical trials are promising. Recent randomized controlled trials have not found high-dose biotin supplementation to be beneficial in the treatment of multiple sclerosis. (More information)īiotin is used in the treatment of biotin-thiamin responsive basal ganglia disease, an inherited disorder of thiamin transport. Yet, it is not known if marginal biotin deficiency during pregnancy increases the risk for congenital anomalies in humans. (More information)Īnimal studies have shown that biotin sufficiency is essential for normal fetal development. Biotin requirements are likely increased during pregnancy and breast-feeding. The recommended adequate intake ( AI) of biotin is set at 30 micrograms (μg)/day in adults. (More information)īiotinidase deficiency is a rare hereditary disorder that impairs biotin absorption and recycling, resulting in secondary biotin deficiency. (More information)īoth parenteral nutrition devoid of biotin and prolonged consumption of raw egg white have been associated with symptoms of frank biotin deficiency, including hair loss, dermatitis, skin rash, ataxia, seizures, and other neurologic dysfunctions. Water-soluble biotin is an essential cofactor to enzymes in intermediary metabolism and a key regulator of gene expression.
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